![]() 7 Three key indicators to help identify CRS among affected patients have been reported by Fajgenbaum, et al., namely, pronounced levels of cytokines, acute systemic inflammation, and secondary organ dysfunction. 6 The overly reactive immune response, referred to as cytokine release syndrome (CRS), is an umbrella term that typifies numerous life-threatening clinical manifestations engendered by severe and acute COVID-19 infections, where the immune system starts producing excessive inflammatory signals, thus causing deleterious health effects on the affected host. While the cause of severe SARS-CoV-2 syndrome is not fully understood, an excessive inflammatory response typically plays the major role. ![]() 2 Researchers have reported the efficacy of Remdesivir, an antiviral drug previously used against the Ebola virus 3 other studies have shown ineffective results when previously known antiviral drugs were used against severe COVID-19 diseases. 1 Despite the severe negative impact of the disease on the healthcare system, there are still no effective therapeutic treatments. The prevailing COVID-19 pandemic, otherwise known as SARS-CoV-2, has been confirmed in more than 494.6 M people and caused 6.2 M deaths globally.
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